Rabbits & ecology- archaeologically speaking

Joel is a geneticist working with archaeological remains

 

joel alves profile pic

Joel Alves is a Postdoctoral Researcher here at the School of Archaeology in Oxford.

As a geneticist working in an archaeology setting, his research sits at the intersection of natural and social sciences. Most of his work uses DNA from contemporary and archaeological populations to investigate how humans and the environment have shaped the genomes of species. He is interested in a broad spectrum of topics, ranging from the process of domestication to the adaptation to novel habitats.

He joined the School In 2018 and is currently leading research projects that use Ancient DNA to investigate how humans and animals, such as rabbits, have interacted through time.

 

Working with a multidisciplinary international team of researchers who specialise in ecology and genetics, Joel has helped to pinpoint the origins of the fastest colonisation rate for an introduced mammal ever recorded.

rabbit wiki

Photo from Wikipedia

The European rabbit, Oryctolagus cuniculus, was originally introduced to mainland Australia in 1788 but despite nearly 100 more importations, the rabbit population only exploded in the latter half of the 19th century. In 1859 Thomas Austin, in trying to recreate an ‘English Landscape’ on his estate in Victoria, received a consignment of 24 wild and domestic rabbits from his brother in Somerset. Within three very productive years, the rabbits multiplied their numbers into the thousands. Within 50 years rabbits had spread across the entire continent at an astonishingly rate of 100km per year. This was a very successful rabbit invasion!

The researchers on this project traced DNA found in the mitochondria of cells – which is inherited from the mother – in present day Australian rabbits and discovered the genetic similarities to rabbits in south-west of England. They also discovered that some rare genetic variants in the Australian rabbits increased with distance from Thomas Austin’s estate.

So why were these Somerset rabbits so successful? This is most likely because of their wild ancestry which gave them a devastating advantage over previously introduced rabbits with domestic origins which had been bred to emphasize traits including tameness and distinct coat colours.

Of course, this invasion wreaked havoc on the indigenous Australian ecology and continues to damage agricultural crops to the cost of $200m each year.

 

The emergence of new infectious diseases can result in intense selective pressures on populations and cause rapid evolutionary change in both host and parasite. Whereas pathogens must adapt to a new ecology and cellular environment, hosts can rapidly evolve resistance in a continuous arms race. One of the most emblematic examples of this coevolutionary process arose when the wild European rabbit (Oryctolagus cuniculus) populations in Australia and Europe were exposed for the first time to the myxoma virus (MYXV) (genus Leporipoxvirus, family Poxviridae). MYXV circulates naturally in American cottontail rabbits (Sylvilagus spp.), where it causes benign skin tumors, but in European rabbits it causes the highly lethal systemic disease myxomatosis.

Photo of Joel and Darwins rabbit

Image caption: Joel Alves and Prof Francis Jiggins and rabbit in the University Museum of Zoology, Cambridge, photo credit: University of Cambrige.

Nearly seventy years after myxomatosis decimated the rabbit populations of Australia, Britain and France, the PhD research by Dr Joel Alves, reveals how the species has evolved genetic resistance to the disease through natural selection.  At a time when rabbit populations are collapsing across the UK and mainland Europe, this research may provide clues to the animal’s future.  

The team collected historical samples from 11 natural history museums in the UK, France, Australia and the United States. One of the rabbits from which DNA was sequenced belonged to Charles Darwin and is now housed in London’s Natural History Museum. Joel Alves said: “It wasn’t easy to get samples from so many long-dead rabbits. Not all natural history museums keep rabbits because they are not very exotic compared to other species. But the museums we worked with have done a great job of keeping their specimens well preserved for decades. This and the availability of new technology gave us a unique opportunity.”

“We compared rabbits collected before the virus outbreak in the 1950s with modern populations that evolved resistance, and found that the same genes had changed in all three countries. Many of these genes play a key role in the rabbit immune system. Often evolution works through big changes in single genes, but our findings show that resistance to myxomatosis likely evolved through lots of small effects spread across the genome.”

Myxomatosis is a viral infection that was deliberately introduced from American cottontail rabbits into European rabbit populations to control their population. Over the past 60 years or so, similar resistance variants have emerged in parallel in the United Kingdom, France, and Australia. Interestingly, it now seems that the virus is counter-evolving immune suppressive traits.

Read the research paper here - https://www.science.org/doi/10.1126/science.aau7285 

 

two photos of the snow shoe hare showing the summer and winter coats

The Snow shoe hare showing the summer and winter coats. Photo from Wikipedia

Many animals have evolved fur or feather colours to blend in with the environment and hide from predators. But how do animals stay camouflaged when their environment changes with each new season? In other words, how does a white rabbit hide once the snow has melted?

An international research team, including Dr Joel Alves, has discovered that hybridization played an important role in the snowshoe hares' ability to match their environment. The North American snowshoe-hare bred with black-tailed jackrabbits which provided them with the critical coat colour variation needed to darken their fur for warmer climes.

In the winter the hares have evolved to molt their brown fur to reveal a white coat. In milder, coastal environments they retain their brown fur all year round. Brown winter coats are currently rare across the range of these winter favouring hares.

The team discovered that the development of brown or white winter coats in snowshoe hares is controlled by genetic variation at a single pigmentation gene that is activated during the autumn molt. This shows that critical adaptive shifts in seasonal camouflage can evolve through changes in the regulation of a single gene.

What does climate change mean for the future of the snow-loving hare? If snow covers continues to decrease due to climate change, brown winter coats may become more common in the future and play a critical role in the resilience of the species.

Read the research paper here - Adaptive introgression underlies polymorphic seasonal camouflage in snowshoe hares.